| Drugs A-Z
|
Glyburide
Generic Name: Glyburide
Brand Name: Micronase
Indications
Micronase Tablets are indicated as an adjunct to diet to lower the blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily con- trolled by diet alone.
Dosage and Administration
Micronase tablets are available for oral administration as 1.25mg, 2.5mg and 5mg tablets.
Normal Dosage:
There is no fixed dosage regimen for the management of diabetes mellitus with MICRONASE Tablets or any other hypoglycemic agent. In addition to the usual monitoring of urinary glucose, the patient's blood glucose must also be monitored periodically to determine the minimum effective dose for the patient; to detect primary failure, ie, inadequate lowering of blood glucose at the maximum recommended dose of medication; and to detect secondary failure, ie, loss of adequate blood glucose lowering response after an initial period of effectiveness. Glycosylated hemoglobin levels may also be of value in monitoring the patient's response to therapy.
Short-term administration of MICRONASE may be sufficient during periods of transient loss of control in patients usually controlled well on diet.
Overdose: Overdose symptoms include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.
Drug Description
The chemical name for glyburide is 1-[ [p-[2-(5-chloro-o-anisamido)-ethyl]phenyl]-sulfo- nyl]-3-cyclohexylurea and the molecular weight is 493.99. The structural formula is represented below.
Side Effects
- Stop taking this medication and seek emergency medical attention if you experience an allergic reaction
- Low blood sugar may occur when too much glyburide is taken, or due to skipped meals,or if you exert youself,during illness, especially with vomiting or diarrhea,and if you take other medicines.
- Hypoglycemia or Low blood sugar has the following symptoms:
- headache
- cold sweats
- anxiety
- Hyperglycemia or High blood sugar has the following symptoms:
- increased thirst
- increased hunger
- There may be an increased risk of death due to cardiovascular (heart and blood vessels) complications with the use of this drug when compared to the treatment of diabetes with diet or diet plus insulin.
- Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or is especially bothersome.
Precautions
- Avoid alcohol. It lowers blood sugar and may interfere with diabetes treatment.
- Before taking this medicaion, tell your doctor if you:
- have kidney disease
- have liver disease
- have thyroid disease
- have type 1 diabetes
- have a serious infection, illness, or injury
- need surgery
You may require a special dosage or monitoring during treatment if you have any of the conditions listed above.
- Patients 65 years of age and older may have a stronger reaction and may require a reduced dose.
- This drug belongs to the class of the FDA pregnancy category C and this means that taking this drug during pregnancy may affect the foetus. You are advised to consult your doctor about your health conditions in detail.
Drug Interactions
Many other medicines may increase or decrease the effects of this medication or affect your condition. Before taking this medication, tell your doctor if you are taking any of the following medicines:
- aspirin or another salicylate such as magnesium/ choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol)
- a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), naproxen (Anaprox, Naprosyn, Aleve), and others
- a sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin), or sulfasalazine (Azulfidine)
- a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil)
- a beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor), and others
- a diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril), and others
|
