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Daypro
Generic Name: Oxaprozin
Brand Name: Daypro
Indications
Daypro is indicated for the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis
Dosage and Administration
Dapro is usually available for oral administration as 600mg caplets.
Normal Dosage:
Rheumatoid arthritis: For relief of the signs and symptoms of rheumatoid arthritis, the usual recommended dose is 1200 mg (two 600-mg caplets) given orally once a day.
Osteoarthritis: For relief of the signs and symptoms of osteoarthritis, the usual recommended dose is 1200 mg (two 600-mg caplets) given orally once a day.
Overdose: Overdose symptoms may include nausea, vomiting, dizziness, drowsiness, black or bloody stools, coughing up blood, fever, urinating less than usual or not at all, shallow breathing, fainting, or coma.
Drug Description
Daypro is a nonsteroidal anti-inflammatory drug (NSAID), chemically designated as 4,5-diphenyl-2-oxazole-propionic acid, and has the following chemical structure:
The empirical formula for oxaprozin is C18H15NO3, and the molecular weight is 293. Oxaprozin is a white to off-white powder with a slight odor and a melting point of 162°C to 163°C. It is slightly soluble in alcohol and insoluble in water, with an octanol/water partition coefficient of 4.8 at physiologic pH (7.4). The pKa in water is 4.3.
Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty in breathing; swelling of your face, lips, tongue, or throat.
Stop taking oxaprozin and seek medical attention or call your doctor at once if you have any of these serious side effects:
- chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance
- black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds
- urinating less than usual or not at all
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
- bruising, severe tingling, numbness, pain, muscle weakness
Less serious side effects may include:
- upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas
- dizziness, headache, nervousness
- skin itching or rash
- dry mouth
- increased sweating, runny nose
- blurred vision; or
- ringing in your ears
This is not a complete list of the side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
Precautions
- Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain medicines similar to oxaprozin (such as aspirin, ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
- Do not drink alcohol while taking oxaprozin. Alcohol can increase the risk of stomach bleeding.
- Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
- NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.
- Do not use this medication if you are allergic to oxaprozin, or to aspirin or other NSAIDs.
- Before taking oxaprozin, tell your doctor if you are allergic to any drugs, or if you have:
- a history of heart attack, stroke, or blood clot
- heart disease, congestive heart failure, high blood pressure
- a history of stomach ulcers or bleeding, bowel problems, diverticulosis
- liver or kidney disease
- asthma
- polyps in your nose; or
- if you smoke
If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.
- FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking oxaprozin during the last 3 months of pregnancy may result in birth defects. Do not take oxaprozin during pregnancy unless your doctor has told you to.
- Oxaprozin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
- Do not give this medicine to a child younger than 6 years old without the advice of a doctor.
Drug Interactions
Before taking oxaprozin, tell your doctor if you are taking any of the following drugs:
- cyclosporine (Gengraf, Neoral, Sandimmune)
- lithium (Eskalith, Lithobid)
- a blood thinner such as warfarin (Coumadin)
- steroids (prednisone and others); or
- aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others
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