Cimetidine

Generic Name: Cimetidine
Brand Name: Tagamet

Indications
Cimetidine is indicated for the treatment of peptic ulcers by decreasing the secretion of stomach acid.
Dosage and Administration

Cimetidine is available as 300mg, 400mg and 800mg tablets. Cimetdine is also available in liquid form and injection.

Use this medication exactly as directed on the label, or as your doctor has prescribed it for you. Do not use more of the medication than recommended. Do not use the medication for longer than recommended. Cimetidine is usually taken with meals or at bedtime. Take each dose with a full glass of water. To be sure you get the correct dose of the oral solution (liquid), measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Do not stop taking Cimetidine without first talking to your doctor. It may take up to 8 weeks for an ulcer to heal.

Overdose: Symptoms of a cimetidine overdose may include nausea, vomiting, diarrhea, confusion, extreme weakness, or fainting

Drug Description

Tagamet (cimetidine) is a histamine H2-receptor antagonist. Chemically it is N?-cyano-N-methyl N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-guanidine. The empirical formula for cimetidine is C10H16N6S and for cimetidine hydrochloride, C10H16N6SHCl; these represent molecular weights of 252.34 and 288.80, respectively.

Cimetidine contains an imidazole ring, and is chemically related to histamine. (The liquid and injection dosage forms contain cimetidine as the hydrochloride.) Cimetidine has a bitter taste and characteristic odor.

 

Side Effects

Stop using cimetidine and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty in breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

• cough, fever, chest congestion, trouble in breathing;
• red or blistering skin rash;
• jaundice (yellowing of the skin or eyes);
• easy bruising or bleeding, unusual weakness;
• feeling faint, light-headed, disoriented, or confused;
• urinating less than usual;
• irregular heartbeat; or
• a rash.

Other less serious side effects are more likely to occur. Talk with your doctor if you have any of these side effects:

• feeling dizzy, depressed, or agitated;
• breast swelling or tenderness (in men);
• joint or muscle pain;
• mild skin rash;
• headache; or
• diarrhea, nausea, or constipation.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or  is especially bothersome.

Precautions

• Avoid taking antacids unless your doctor recommends them for heartburn pain. Follow your doctor's advice about the type of antacid to use and when to use it. You may not be able to take the antacid at the same time you take your dose of cimetidine.
• Taking cimetidine may make you more susceptible to virus that causes pneumonia. You may be more likely to develop pneumonia if you have certain health problems.
• Before using this medication, tell your doctor if you have:
• diabetes
• asthma or a chronic lung disorder
• a weak immune system
• bone marrow suppression
• kidney disease
• liver disease
• If you have any of the conditions listed above, you may not be able to use cimetidine or you may need a dosage adjustment or special tests during treatment.
• Cimetidine is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use this medication without telling your doctor if you are pregnant or plan to become pregnant during treatment.
• Cimetidine passes into breast milk, and may be harmful to a nursing baby. Do not take cimetidine without telling your doctor if you are breast-feeding a baby.
• Do not give this medicine to a child younger than 16 years old unless your doctor has told you to.

Drug Interactions
If you also take ketoconazole (Nizoral), take it at least 2 hours before you take cimetidine.
Before taking this medication, tell your doctor if you are using any of the following medicines:

• a blood thinner (warfarin or Coumadin)
• phenytoin (Dilantin)
• nifedipine (Adalat)
• metronidazole (Flagyl)
• propranolol (Inderal)
• chlordiazepoxide (Librium)
• lidocaine (Xylocaine)
• diazepam (Valium)
• theophylline (Theo-Dur, Slo-Bid, Bronkodyl)
• depression or anxiety medication such as amitriptyline (Elavil), imipramine (Tofranil), clomipramine (Anafranil), desipramine (Norpramin), nortripytyline (Aventyl).

You may not be able to take cimetidine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
There may be other drugs not listed that can affect cimetidine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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