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Buspar
Generic Name: Buspirone
Brand Name: Buspar
Indications
BuSpar is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety.
Dosage and Administration
BuSpar is supplied as tablets for oral administration containing 5 mg, 10 mg, 15 mg, or 30 mg of buspirone hydrochloride.
Normal Dosage: recommended is an initial dose of 15 mg daily.
Overdose?
Some of the overdose symptoms are nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress
Drug Description
Buspirone hydrochloride is a white crystalline, water soluble compound with a molecular weight of 422.0. Chemically, buspirone hydrochloride is 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-aza-spiro[4.5]decane-7,9-dione monohydrochloride. The empirical formula C21H31N502•HCl is represented by the following structural formula:
Side Effects
Common noted side effects are dizziness, insomnia or drowsiness, nausea, light headedness or even complaints regarding the nervous system, fatigue, muscle stiffness.
Precautions
- Be careful if you drive or do anything that requires you to be awake and alert while administering this medicine.
- Avoid drinking alcohol. It may increase some of the side effects caused by buspirone.
- Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, or depression can add to sleepiness caused by buspirone.
- Grapefruit and grapefruit juice may interact with buspirone and lead to potentially dangerous effects.
Drug Interactions
The following drugs can interact with buspirone. Try avoiding them while using buspar
- medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);
- dexamethasone (Decadron, Hexadrol);
- erythromycin (E-Mycin, E.E.S., Ery-Tab, Erythrocin);
- itraconazole (Sporanox), ketoconazole (Nizoral);
- ritonavir (Norvir);
- rifampin (Rifadin, Rimactane, Rifater);
- antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled);
- a calcium channel blocker such as diltiazem (Tiazac, Cartia, Cardizem) or verapamil (Calan, Covera, Isoptin, Verelan); or
- seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), phenobarbital (Luminal, Solfoton).
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