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Bumex
Generic Name: Bumetanide
Brand Name: Bumex
Indications
Bumex is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome.
Dosage and Administration
Bumex is available as scored tablets, 0.5 mg, 1 mg and 2 mg for oral administration.
Normal Dosage: recommended is 0.5 mg to 2 mg and in most patients is given as a single dose.
Overdose?
Overdosage can lead to acute profound water loss, volume and electrolyte depletion, dehydration, reduction of blood volume and circulatory collapse with a possibility of vascular thrombosis and embolism.
Drug Description
Chemically, bumetanide is 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid. It is a practically white powder having a calculated molecular weight of 364.41, and the following structural formula:
Side Effects
The most frequent side effects with Bumex are muscle cramps, dizziness, hypotension, headache, nausea, chest pain, diarrhea and so on.
Precautions
- Avoid becoming dehydrated.
- This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
- Nursing mothers should seek advise before taking the medicine.
- Before using this medication, tell your doctor if you have kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs.
- To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested.
Drug Interactions
Avoid the following while taking this medication
- Lithium (Lithobid, Eskalith, others)
- probenecid (Benemid)
- a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin), naproxen (Naprosyn, Anaprox, Aleve), ketoprofen (Orudis, Orudis KT, Oruvail), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), etodolac (Lodine), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), fenoprofen (Nalfon), ketorolac (Toradol), or flurbiprofen (Ansaid)
- a diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase)
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