Agenerase
Generic name: Amprenavir
Brand Name: Agenerase
Indications
Agenerase is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.
Dosage and Administration
Agenerase Capsules, 50 mg, are oblong, opaque, off-white to cream-colored soft gelatin capsules printed with “GX CC1” on one side.
Agenerase Oral Solution, a clear, pale yellow to yellow, grape-bubblegum-peppermint- flavored liquid, contains 15 mg of amprenavir in each 1 mL.
Agenerase may be taken with or without food; however, a high- fat meal decreases the absorption of amprenavir and should be avoided. Adult and pediatric patients should be advised not to take supplemental vitamin E since the vitamin E content of Agenerase Capsules exceeds the Reference Daily Intake (adults 30 IU, pediatrics approximately 10 IU).
Adults: The recommended oral dose of Agenerase Capsules for adults is 1,200 mg (twenty- four 50- mg capsules) twice daily in combination with other antiretroviral agents.
Pediatric Patients:
13 to 16 years: the recommended oral dose of Agenerase Capsules is 1,200 mg (twenty- four 50- mg capsules) twice daily in combination with other antiretroviral agents.
4 to 12 years or 13 to 16 years of age with weight of < 50 kg: the recommended oral dose of Agenerase Capsules is 20 mg/kg twice daily or 15 mg/kg 3 times daily (to a maximum daily dose of 2,400 mg) in combination with other antiretroviral agents.
Overdose?
Over dosage of Agenerase results in rapid palpitation, fatigue, dizziness or lightheadedness.
Drug Description
AGENERASE (Amprenavir) is an inhibitor of the human immunodeficiency virus (HIV) protease. The chemical name of amprenavir is (3S)-tetrahydro-3-furyl N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl]carbamate. Amprenavir is a single stereoisomer with the (3S)(1S,2R) configuration. It has a molecular formula of C25H35N3O6S and a molecular weight of 505.64. It has the following structural formula:
Amprenavir is a white to cream-colored solid with a solubility of approximately 0.04 mg/mL in water at 25°C.
Agenerase Capsules are available for oral administration. Each 50- mg capsule contains the inactive ingredients d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), polyethylene glycol 400 (PEG 400) 246.7 mg, and propylene glycol 19 mg. The capsule shell contains the inactive ingredients d-sorbitol and sorbitans solution, gelatin, glycerin, and titanium dioxide. The soft gelatin capsules are printed with edible red ink. Each 50- mg Agenerase Capsule contains 36.3 IU vitamin E in the form of TPGS. The total amount of vitamin E in the recommended daily adult dose of Agenerase is 1,744 IU.
Side Effects
Some of the side effects commonly observed are depression, muscular pain or having trouble in breathing, abdominal pain, wheezing, fatigue, loss of appetite and difficulty in breathing.
Precautions
- HIV-positive patients administering Agenerase should avoid taking vitamin E supplements.
- Drinking alcoholic beverages is not recommended while taking the Agenerase because it may increase the side effects.
- Before taking amprenavir, tell your doctor if you have an allergy to "sulfa" drugs, diabetes, liver disease, hemophilia
Drug Interactions
Some of the drugs that does not go with Agenerase are:
- cisapride(Propulsid)
- rifampin(Rifadin,Rimactane)
- pimozide(Orap)
- amiodarone(Cordarone)
- bepridil(Vascor)
- ritonavir (Norvir)
During the treatment you should not take the drugs such as heartburn medications, antibiotics, antihistamines, calcium channel blockers, cholesterol-lowering drugs, sedatives
